MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000251

[Pediatric multiple sclerosis: is it different from the adult form?].

Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252

[Pediatric multiple sclerosis: is it different from the adult form?].

Auteurs : A. Araqi-Houssaini [Maroc] ; F. Dany [Maroc] ; Z. Sekkat [Maroc] ; N A Camara [Maroc] ; A. Hazim [Maroc] ; N. Midafi [Maroc] ; H. Elotmani [Maroc] ; B. El Moutawakil [Maroc] ; M A Rafai [Maroc] ; I. Slassi [Maroc]

Source :

Revue neurologique [ 0035-3787 ]

RBID : pubmed:25174885

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Sclérose en plaques (diagnostic), Âge de début (MeSH), Études rétrospectives (MeSH), Évolution de la maladie (MeSH).
MESH :
- diagnostic : Sclérose en plaques.
- Adolescent, Adulte, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Âge de début, Études rétrospectives, Évolution de la maladie.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age of Onset (MeSH), Child (MeSH), Child, Preschool (MeSH), Disease Progression (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Multiple Sclerosis (diagnosis), Retrospective Studies (MeSH), Young Adult (MeSH).
MESH :
- diagnosis : Multiple Sclerosis.
- Adolescent, Adult, Age of Onset, Child, Child, Preschool, Disease Progression, Female, Humans, Male, Retrospective Studies, Young Adult.

Abstract

INTRODUCTION

Multiple sclerosis (MS) is not uncommon in children. The aim of this study was to compare early onset MS (EOMS) with adult onset MS (AOMS).

METHODS

A retrospective study including MS cases between 1997 and 2010. EOMS was defined by age at MS onset<18years. Data were collected using the EDMUS database (European Database of Multiple Sclerosis) including: sex, age at onset, disease duration, EDSS, score after relapse. The MSSS and the Progression Index were calculated. Patients with disease duration less than one year were excluded. MS symptoms at onset and at further relapses were also noted. These parameters were compared between the EOMS and the AOMS groups.

RESULTS

Two hundred fifty-nine cases were included including 31 EOMS (11.96%). The mean follow-up was 96months. The relapsing-remittent form was significantly more frequent in the pediatric group (94% vs 79%). Mean EDSS and MSSS scores and the percentage of fast progressors (MSSS>5) were lower in the EOMS group. Analysis of neurological symptoms at the first MS attack and further neurological events showed a lower frequency of gait disturbances, motor symptoms and bladder symptoms in the EOMS group compared with the AOMS group. The 10-year mean EDSS score was 1.9 for EOMS and 4.1 for AOMS, after 25years it was 4.5, and 7.27 respectively.

CONCLUSION

This study highlights the relative frequency of EOMS in our MS population. However, different severity scores showed less disability progression in EOMS patients compared with AOMS patient; irreversible disability was reached at an early age.

DOI: 10.1016/j.neurol.2014.07.004
PubMed: 25174885

Affiliations:

Maroc

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Age of Onset (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Disease Progression (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Multiple Sclerosis (diagnosis)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Sclérose en plaques (diagnostic)</term>
<term>Âge de début (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
<term>Évolution de la maladie (MeSH)</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple Sclerosis</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Sclérose en plaques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age of Onset</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Âge de début</term>
<term>Études rétrospectives</term>
<term>Évolution de la maladie</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>Multiple sclerosis (MS) is not uncommon in children. The aim of this study was to compare early onset MS (EOMS) with adult onset MS (AOMS).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>A retrospective study including MS cases between 1997 and 2010. EOMS was defined by age at MS onset<18years. Data were collected using the EDMUS database (European Database of Multiple Sclerosis) including: sex, age at onset, disease duration, EDSS, score after relapse. The MSSS and the Progression Index were calculated. Patients with disease duration less than one year were excluded. MS symptoms at onset and at further relapses were also noted. These parameters were compared between the EOMS and the AOMS groups.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Two hundred fifty-nine cases were included including 31 EOMS (11.96%). The mean follow-up was 96months. The relapsing-remittent form was significantly more frequent in the pediatric group (94% vs 79%). Mean EDSS and MSSS scores and the percentage of fast progressors (MSSS>5) were lower in the EOMS group. Analysis of neurological symptoms at the first MS attack and further neurological events showed a lower frequency of gait disturbances, motor symptoms and bladder symptoms in the EOMS group compared with the AOMS group. The 10-year mean EDSS score was 1.9 for EOMS and 4.1 for AOMS, after 25years it was 4.5, and 7.27 respectively.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>This study highlights the relative frequency of EOMS in our MS population. However, different severity scores showed less disability progression in EOMS patients compared with AOMS patient; irreversible disability was reached at an early age.</p>
</div>
</front>
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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000251 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000251 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    MaghrebDataLibMedV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25174885
   |texte=   [Pediatric multiple sclerosis: is it different from the adult form?].
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25174885" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MaghrebDataLibMedV2

This area was generated with Dilib version V0.6.38.
Data generation: Wed Jun 30 18:27:05 2021. Site generation: Wed Jun 30 18:34:21 2021

	Serveur sur les données et bibliothèques médicales au Maghreb (version finale)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur sur les données et bibliothèques médicales au Maghreb (version finale)

[Pediatric multiple sclerosis: is it different from the adult form?].

[Pediatric multiple sclerosis: is it different from the adult form?].

Source :

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Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki